2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121685
    Tipepidine 5169-78-8 98%
    Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect.
    Tipepidine
  • HY-121704
    SR 57227A free base 77145-51-8 98%
    SR 57227A Free base is a highly selective compound for both peripheral and central 5-HT3 receptors and acts as an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells, demonstrating antidepressant-like effects in rats while reducing isolation-induced aggressive behavior.
    SR 57227A free base
  • HY-121711
    5-OH-HxMF 1176-88-1 98%
    5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities.
    5-OH-HxMF
  • HY-121751
    A 643C 65822-42-6 98%
    A 643C is an investigative antidepressant.
    A 643C
  • HY-121775
    PF-00217830 846032-02-8 98%
    F-00217830 is an agonist ofDopamine D2 receptor. PF-00217830 inhibits of spontaneous locomotor activity and 2,5-dimethoxy-4-iodoamphetamine-induced head twitches in rats.
    PF-00217830
  • HY-121778
    Melitracen 5118-29-6 98%
    Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety.
    Melitracen
  • HY-121813
    Rimcazole 75859-04-0 98%
    Rimcazole (BW 234U) is a potent antipsychotic agent. Rimcazole also is a competitive antagonist of sigma sites. Rimcazole can be used for the research of acute schizophrenic diseases.
    Rimcazole
  • HY-121850
    Rolicyprine 2829-19-8 98%
    Rolicyprine (EX-4883) is an antidepressant with neuroprotective activity. Rolicyprine can improve depressive symptoms and promote neuroregeneration. Rolicyprine also shows potential effectiveness for anxiety suppression.
    Rolicyprine
  • HY-121886
    Bucricaine 316-15-4 98%
    Bucricaine is an anesthetic compound with analgesic activity. Bucricaine is used in clinical anesthesia to reduce pain during surgery. The mechanism of action of Bucricaine involves inhibition of nerve signaling. Bucricaine's applications include local anesthesia and dental anesthesia. Bucricaine is widely used during surgery and other medical procedures to improve patient comfort.
    Bucricaine
  • HY-121906
    DOAM 63779-90-8 98%
    DOAM is an antagonist of 5-HT2 receptor.
    DOAM
  • HY-12190A
    JNJ-5207852 dihydrochloride 1782228-76-5 98%
    JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
    JNJ-5207852 dihydrochloride
  • HY-121920
    25C-NBOH hydrochloride 1539266-20-0 98%
    25C-NBOH hydrochloride is a derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine and is a potent agonist of 5-HT receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively).
    25C-NBOH hydrochloride
  • HY-121947
    1'-Naphthoyl-2-methylindole 80749-33-3 98%
    1'-Naphthoyl-2-methylindole (Compound 88) is a cannabinoid mimetics and an inhibitor for Win 55212-2, that inhibits 34% of [3H]Win 55212-2 binding to cannabinoid receptors at 3 μM.
    1'-Naphthoyl-2-methylindole
  • HY-121966
    Riparin 112356-54-4 98.00%
    Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca2+ influx and inhibiting the release of intracellular calcium ion stores.
    Riparin
  • HY-121974
    SR14150 709024-69-1 98%
    SR14150 is a partial agonist of the NOP receptor with high affinity. The biological activity of SR14150 makes it potentially useful for the development of a new generation of multi-target opioids designed to simultaneously improve analgesia and reduce side effects. The activity of SR14150 and its interaction with other opioid receptors may provide new inhibitory options for the management of chronic pain.
    SR14150
  • HY-122001
    PF-05186462 1235406-03-7 99.69%
    PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain.
    PF-05186462
  • HY-122050
    Oe-9000 675132-92-0 98%
    Oe-9000 is a compound with local anesthetic activity that inhibits voltage-gated Na+ currents in neurons, including both TTX-resistant and TTX-sensitive currents, with effects superior to those of some other local anesthetics.
    Oe-9000
  • HY-122069
    NSC177365 80261-18-3 98%
    NSC177365 (NSC 1) is a CcrM inhibitor. NSC177365 is a competitive DNA inhibitor and disrupts DNA binding. NSC177365 has antibacterial activity, with IC50s of 2.3 and 14.6 μM for C. crescentus and M. lincolnii respectively. NSC177365 reverses several neurodegenerative disorders and serve as an anticancer agent.
    NSC177365
  • HY-122070
    Tirilazad mesylate 110101-67-2 98%
    Tirilazad mesylate (U 74006F) is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research.
    Tirilazad mesylate
  • HY-122080
    Memoquin 616885-87-1 98%
    Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).
    Memoquin
Cat. No. Product Name / Synonyms Application Reactivity